Cardiac Surgery Research

Clinical Research

Research is an integral part of our mission in the Weill Cornell Department of Cardiothoracic Surgery. We strive to understand the pathophysiologic mechanisms of cardiovascular disease, develop and improve treatment methodologies, and improve the quality of the care that we offer. We have an active clinical and translational research center that focuses on the major cardiovascular disorders including coronary artery disease, heart valve disorders, and aortic pathologies, such as aneurysms and other aortopathies.

Clinical Trials

Our department participates in numerous national trials sponsored by industry representatives. We participate in studies to evaluate a variety of novel cardiac implants, such as innovative heart valve implants, heart valve repair techniques, aortic grafts, ventricular assist devices, and end-organ preservation devices. Learn more

  • Aortic Disease

  • Coronary Artery Disease

  • Atrial Fibrillation

  • Valvular Disease

Our Researchers

<a href="">Leonard N Girardi, M.D.</a>

Leonard N Girardi, M.D.

Chair of Cardiothoracic Surgery

<a href="">Mario FL Gaudino, M.D.</a>

Mario FL Gaudino, M.D.

Assistant Dean of Clinical Research;
Director of the JCTO;
Director of Translations and Clinical Research

<a href="">Stephanie L Mick, M.D.</a>

Stephanie L Mick, M.D.

Associate Professor of Cardiothoracic Surgery

<a href="">Christopher Lau, M.D.</a>

Christopher Lau, M.D.

Associate Professor of Cardiothoracic Surgery

Director of Research Administration

Murtaza Malbari, MS

Murtaza Malbari, MS

Director of Research Administration
Phone: (212) 746-9400
Fax: (212) 746-9393


A multi-institutional team of scientists led by Dr. Mario Gaudino, the Stephen and Suzanne Weiss Professor in Cardiothoracic Surgery and assistant dean for clinical trials at Weill Cornell Medicine, has been approved for a nearly $30 million funding award from the Patient-Centered Outcomes Research Institute (PCORI). Learn More

The ROMA Trial

Dr. Gaudino is also one of the Principal Investigators of The ROMA Trial, a two-arm event-driven randomized multi-center trial aimed at evaluating the impact of the use of one ITA vs two or more AGs for CABG on a composite of death from any cause, any stroke, and post-discharge myocardial infarction and/or repeat revascularization.


Dr. Mario Gaudino is the newly appointed director of the Joint Clinical Trials Office (JCTO) at Weill Cornell Medicine | NewYork-Presbyterian, Dr. Gaudino oversees ongoing clinical trials and lead strategic planning efforts.

Weill Cornell Medicine Cardiothoracic Surgery 525 East 68th Street
Box 110
Suite M 404
New York, NY 10065 Directions
Phone: (212) 746-5166


Scientists Detail Major Mechanism Lung Cancers Use to Evade Immune Attack

A protein commonly found at high levels in lung cancer cells controls a major immunosuppressive pathway that allows lung tumors to evade immune attack, according to a study led by researchers at Weill Cornell Medicine. The discovery could hasten the development of treatments that overcome this tumor defense mechanism and improve outcomes for lung cancer patients. Click...

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Surgical Mitral Repair or Mitral Clip for Degenerative Mitral Valve Regurgitation?

We are enrolling in this NIH sponsored trial investigating surgical mitral valve repair versus mitral clip in patients 65 years old or older, of any risk status.  Patients suitable for surgery or clip are randomized to the procedure, and will be followed for 10 years.

From Clinical


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Reducing Copper in the Body Alters Cancer Metabolism to Reduce Risk of Aggressive Breast Cancer

Transmission electron microscopy images

Transmission electron microscopy images...

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